Flexible, modular system for the early assessment of the cardiotoxic potency of the new chemical entities. The Tox-Comp.net platform consists of the interconnected elements: hERG other ionic channels inhibition calculator, human left ventricular cell model and virtual populations creator.
Independent tool for prediction of the hERG channel inhibition potential. Random Forests and artificial neural network based models. Input data consists of calculated physico-chemical descriptors of the chemical entities and in vitro experiment conditions.